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“The measures reflect a expanding physique of investigation about discrepancies among journal articles and the full results of the research behind them. Journal editors are also responding to the escalating debate in Washington on making certain drug side effects are appropriately disclosed. In the wake of the withdrawal of Merck & Co.’s painkiller Vioxx more than cardiovascular side effects, some legislators are calling for tougher security scrutiny of drugs on the marketplace.

The JAMA toomsboro square ottoman study final year said articles generally cherry-picked powerful final results to report, even if those final results were in a unique location than the study was designed to test. Generally scientists set up clinical trials to answer one particular or two key concerns — for example, irrespective of whether a drug reduces the threat of a heart attack and stroke. These are referred to as the primary outcomes. The JAMA study identified that 62% of trials had at least one main outcome that was changed, added or omitted.”

(Source: the Wall Street Journal)

UPDATE three/25/07: We have removed our spoof image of JAMA’s cover due to the fact some of our readers have alerted us that, upon closer inspection, the thumbnail of the JAMA concern, which depicts a cartoon examination scene, consists of nudity. This was a full, unintentional oops on our portion! No offense was intended. (Though we have to wonder…why on earth is JAMA placing these sorts of depictions in their cover art in the first place?)

It’s no surprise any longer that the big medical journals are plastered with pharmaceutical advertisements – right after all, when was the last time you visited a medical professional’s office that wasn’t drowning in pharmaceutical advertising widgets? Nor is it a surprise that the very research in medical journals (not the advertisements) are deceptively skewed in Large Pharma’s favor about two-thirds of the time.

I would feel physicians and researchers would be appalled by the replete corruption. But when your personal federal government spends extra time telling you that vitamins are deadly – mainly because a handful of terminally ill individuals weren’t able to stave off inevitable death with a dose of knowingly worthless synthetic E – than it does being concerned about 60,000+ deaths from one particular drug alone, is it any wonder? That’s Isabelle & Max a lot of folks – that’s additional than a lot of whole cities!

For decent men and women, it’s just a all-natural inclination to trust authorities claiming to be each knowledgeable and ethical. Right after all, that’s what we’re paying them for. The difficulty is, the pharmaceutical companies are paying them much more – to the tune of 19 billion dollars. I have no doubt that quite a few folks operating in the pharmaceutical industry are there with the finest of intentions. I am not against drugs vital to improve and save lives, of which there are quite a few successes.

But I do have a problem with an overly-lenient and largely voluntary drug approval approach that is a mockery of ethical standards. Due to the fact we trust journals and physicians so implicitly, we forget that, like any small business, pharmaceuticals are in it for the dollars. It’s just business enterprise. Often, the small business creates good but increasingly, it doesn’t, and the guardians of public overall health – the FDA, peer-reviewed journals, physicians – are, at ideal, manipulated, toomsboro square ottoman and at worst, corrupt.

Can you envision if 60,000 people died from, say, something but a federally-authorized pharmaceutical? Say, echinacea. Grape juice. Ketchup. Something – picture the outcry.

I want this have been a conspiracy theory. I wish this had been a minor problem. I want people could say, “There goes Sisson with his indignant ranting again.”

But the facts are clear:

– Pharmaceutical research are deceptive at least 62% of the time,

– The FDA, through a combination of voluntary adherence protocols and a poorly-developed approval course of action that rushes drugs by means of and fails to adequately stick to up, inherently supports unnecessary deaths,

– Main journals such as JAMA can’t claim to be independent – come on! – when their advertisers are, by and big, pharmaceutical corporations,

– Outcome: hundreds of thousands of people are sickened or killed by drugs every single toomsboro square ottoman year.

Can you imagine if these shenanigans went on in any other sector?

It’s like that humorous response Jack Welch gave to Bill Gates for claiming computers had been much more trustworthy than cars (an urban legend, by the way, but nevertheless entertaining).

Let’s contact a spade a spade.

Is it actually so “outrageous” to have a dilemma with drug ads in healthcare journals?

Is it that “paranoid” to demand a far more rigorous FDA approval approach?

Is it “off-the-wall” to be bothered by the reality that I have to wade through an avalanche of pens, post-it pads and coffee mugs from GlaxoSmithKline each and every time I go to the doctor? If that tends to make me “radical”…

We reside in an marketing age – everything is brought to you by something else, and sports stadiums are named soon after office gear. I can’t catch a game without the need of becoming reminded to go stock up on ink cartridge refills. So it’s no surprise, I guess, that this extends to drugs. If pharmaceuticals are saving hundreds of thousands of lives annually, but at a price of thousands of lives, let’s at least be honest about the costs in terms of human lives. Who is rational and who is emotional right here? The people questioning the disparity involving the advertising and the information, or the economically-motivated (read: fearful) people deriding any one who criticizes them as “radical”?